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[DOI] [PMC free article] [PubMed] [Google Scholar] Chamas et al

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H., Bergmann, M

Wing RR, Koeske R, Epstein LH, Nowalk MP, Gooding W, Becker D

(2011) published that, beyond hypermethylation, chromatin remodeling by a combinatorial complex between estrogen receptor (ER) and endothelial nitric oxide synthase (eNOS) also represses transcription of prognostic genes that are down-regulated in PCa, such as GSTP1

While most TPZ derivatives remain at the preclinical stage, their promising profiles have spurred interest in advancing them into clinical development as part of combination regimens aimed at targeting hypoxia-driven tumor resistance (288, 289)